Do drug trials underestimate side effects?

Sebastian Rushworth |

One commonly used trick in drug trials is to exclude any group that might make the drug look worse, such as those that are more likely to experience side effects. A good recent example of this is the covid vaccine trials, which largely excluded people with auto-immune diseases (more likely to develop an auto-immune disease after vaccination), people with allergies (more likely to have an allergic reaction to the vaccine), and, of course, the elderly (less likely to develop immunity after getting the vaccine, and more likely to become seriously sick from it).

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