National Cancer Institute | ccr.cancer.gov
Researchers at CCR identified a novel modification in human messenger RNA (mRNA) that dramatically impacts gene expression. NAT10, an enzyme, was found to be responsible for the modification, which itself has been implicated in cancer and aging. This is one of the first examples of a unique chemical modification to mRNA (a key factor in deciphering the genetic code) that causes an increase in protein production. The study, by Shalini Oberdoerffer, Ph.D., Investigator in the Laboratory of Receptor Biology and Gene Expression, and colleagues, appeared November 15, 2018, in Cell.