Celiac Disease: Unhealthy or Healthy Response To Wheat?

Sayer Ji
GreenMedInfo

Celiac disease (CD) is increasingly being recognized as a global problem, due in large part to the role that molecular science has played in revealing that the genetic locus of susceptibility for the disease on chromosome 6, known as HLA-DQ2, which is found in 95% of patients with celiac disease, also occurs in 20-30% of healthy patients.¹  Also, in 5% of patients with classically diagnosed celiac disease, the HLA-DQ2 genetic locus is not present at all, revealing that there is no absolute genetic determinant for the disease, and that epigentic factors beyond the control of the gene, such as diet and environmental exposures, play a primarily role.

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