Headlines: ‘Round-the-Clock’ Lifestyle Could Disrupt Metabolism, Brain and Behavior

Source: Science Daily

In Civilization and Its Discontents, Sigmund Freud argued that modern society was hard on human psychology, forcing people to get along in unnaturally close quarters. Now newly published research from The Rockefeller University points out a different discontent in the developed world, namely, the disruption of our natural sleep cycles, thanks to the ubiquity of electric lighting.

Experiments on mice, published this month in Proceedings of the National Academy of Sciences, found that throwing off their evolutionarily ancient circadian rhythms by artificially altering the length of their days has a substantial impact on the body and the brain. The work suggests that our modern, round-the-clock lifestyle could disrupt metabolism, interfere with learning and impact behavior in ways that we’re just beginning to understand.

Researchers led by Ilia Karatsoreos, a postdoc in Bruce S. McEwen’s Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, housed mice for 10 weeks in 20-hour light-dark cycles, at odds with their natural 24-hour circadian cycle. They found that after six weeks, the disrupted mice got fatter, showed less mental flexibility and were more impulsive than mice kept on their natural schedule. The findings were originally presented at a Society for Neuroscience’s conference in 2009.

Looking ahead, Karatsoreos says, a main goal is to understand how this environmental disruption works at the biochemical level. “We are interested in how the light cycle changes affects ‘clock genes’ — the actual molecular gears of the circadian clock within cells — in different brain regions, particularly the prefrontal cortex, and how this translates to changes in the functioning of the cells in that region.”

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1 Response to Headlines: ‘Round-the-Clock’ Lifestyle Could Disrupt Metabolism, Brain and Behavior

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