CINCINNATI—Findings by Cincinnati Cancer Center researchers show that levels of bisphenol A (BPA) in men’s urine could be a marker of prostate cancer and that low levels of BPA exposure can cause cellular changes in both non-malignant and malignant prostate cells.
This research, published in the March 3 edition of PLOS ONE, provides the first evidence that urinary BPA levels may help predict prostate cancer and that disruption of a cell duplication cycle through exposure to low-dose BPA may cause cancer development in the prostate.
BPA, an environmental pollutant with estrogen activity, is used to make hard, clear plastic and is common in many food product containers. It has been linked to neurological defects, diabetes and a number of cancers, including breast and prostate.
No Kevin. This isn’t a breakdown in civility. Your colleagues are at last telling us why you were sacked. And here the political is inescapably personal: you couldn’t run the place. The result was, as Julia Gillard said yesterday and every newspaper and television station has been repeating since, ”chaos and paralysis”.
It still beggars belief that Labor leaders – with or without faces – were unable to pull Rudd into line. They deposed him and decided the government would take the rap. We weren’t told it was Rudd but the Labor government that had lost its way.
The big push in cancer treatment these days is to sample a person’s tumor, test it for mutations, and give the patient a drug tailored to a genetic weak spot in the tumor. A new study suggests one reason why this targeted drug strategy doesn’t always work. A solid tumor, it turns out, is not a mass of identical cancerous cells but a mosaic of genetically different cells that aren’t captured with a single biopsy. Some of these distinct cells may be resistant to the targeted drugs, allowing a tumor to persist or grow.
The classic view of how cancer develops is that a single, normal cell accumulates mutations that eventually allow or force it to divide uncontrollably. This “clone” then grows into a tumor of identical cells, which can also sow seed cells into the bloodstream that then take root somewhere else in the body, or metastasize. The assumption that tumors grow out from a single clone has spurred a rush to find drugs that block one of the clone’s genetic weak spots. But although the strategy has resulted in some very effective drugs—Iressa for lung cancer and a new melanoma drug called Zelboraf, for example—these drugs often stop working within a year or two. One reason could be that solid tumors already harbor a few cells, or clones, with “resistance” mutations that take over when the cells targeted by the drug are wiped out.
Ahead of the Davos summit, Goldman Sachs president Gary Cohn talks to The Sunday Telegraph about the outlook for Europe, the US economy and whether 2012 holds any rays of hope.
For the headquarters of one of the biggest banks in the world, the outside of 200 West Street is deliberately anonymous. Outside, guards patrol in the freezing air and the pavement bollards, masquerading as decorative street furniture, are the type of urban landscaping designed to prevent a terrorist attack. If any reminder were needed, from the upper floors there are views of the reflecting pools that mark Ground Zero.
Although the Occupy Wall Street protesters have been corralled and “moved on” several times by the New York Police Department, Goldman Sachs is not keen to advertise itself. “It’s not as if we’ve got to signal to people where the ATM machines are,” says one senior figure as he accompanies me to the lifts.
Gary Cohn, the president and chief operating Officer of Goldman, is on floor 41, the executive floor. His office, relatively modest for a man who can pick up the phone to almost any CEO in the world, is a couple of doors along from Lloyd Blankfein, the chairman and chief executive.
In this remarkable video from Serbia (English transcript is below), Nikola Aleksic, Director of the Ecological Movement of Novi Sad, issues a stern warning to the president Boris Tadic to stop importing food based upon GMO and stop the chemtrail spraying.
Chinese researchers at Nanjing University have found small segments of rice ribonucleic acid (called microRNA or miRNA for its tiny size) in the blood and organs of people who eat conventional rice. The study does not address how the assimilation of plant RNA into human bodies could affect the debate over the next generation of genetically modified food crops, but the revelation that miRNA can likely survive digestion and take up residence in human cells certainly will provide ammunition for the anti-GMO camp, the most liberal of whom have been calling for toxicological and safety testing of patented plants since the inception of the biotech industry over a decade ago.
Both governmental and private sector representatives will be in attendance; where not only will lucrative deals for provision of contraception will be made, but the BMGF will secure donated funds to bring their brand of depopulation to third world nations.
The BMGF assert that by 2050 “the global population is expected to grow to over 9 billion people” and this is unacceptable to them . By applying pressure to social programs and resources, the BMGF want to use family planning as an investment for all national governments globally.
Delegates at the LFPS will team up with non-governmental organizations like The White Ribbon Alliance for Safe Motherhood (WRA) wherein they have pledged to make sure policies and political leaders are properly swayed in the direction of support their campaign.
Health consultants function as educators and therefore should never prescribe any substance, food, herb, or an over-the-counter medication. Author Francis Brinker recognizes that medicinal herbs should be treated respectfully as they have significant pharmacological activity. His book, Herb Contraindications and Drug Interactions, is directed at both the qualified practitioner and the general population. Majority of herbs in traditional formulas pose no risk to the public, as they are considered mild.
However, their activity could intensify the side effects or toxic reactions to prescription medications. Brinker identifies the herbs that require caution; herb/drug interactions; herbal contraindications for mothers and children; and vitamin/mineral interactions. Herb Contraindications and Drug Interactions approaches interactions from the pharmaceutical side. Using a drug as the starting point, the authors identify which herbs and foods may cause interactions. Below are 5 points based on content from Herb Contraindications and Drug Interactions.
1. Discuss the concerns regarding the increasing popularity and use of herbs.
Physicians, pharmacists and patients need to know that certain herbs when used in combination with pharmaceutical drugs produce contraindications that might have adverse effects on the body. This must be acknowledged and when a patient encounters himself with a serious medical problem, a qualified practitioner should be consulted, not a self medication which might not take into consideration contraindications or drug interaction knowledge.
2. Discuss the concerns regarding the increasing popularity and use of herbs.
Ginseng’s drug interaction are:
Insulin dosage may need adjusting due to hypoglycaemic effects in diabetic patients.
Anticoagulant activity of warfarin may be reduced.
Prelonged (13 weeks) consumption of caffeine may cause hypertension.
If used with monoamine oxidase inhibitor phenelzine may result in manic-like symptoms.
3. Discuss the contraindications associated with guarana.
Guarana’s contraindications are:
Avoid caffeine during pregnancy as increases in caffeine aare present in mother’s milk, has been associated with fetal loss, low birth weight and premature deliveries in humans, and birth defects in animals
Prolonged use may cause insomnia, restlessness, anxiety, irritability, stomach pains and similar effects (all speculative).
Psychological disorders (speculative) can aggravate depression or anxiety neurosis.
Heart disorders (speculative) as caffeine increases heart beat or causes exacerbating arrhythmias (empirical).
Duodenal ulcers (speculative) after increases in gastric acid secretion due to caffeine.
Kidney disorders (speculative) due to the diuretic effect of caffeine.
4. Discuss the contraindications of tobacco.
Tobacco’s contraindications are:
Risk of prematurity, miscarriage and neurological impairment to the baby due to lowered birth weight during pregnancy, possible damage to alveolar septa in the lungs of newborns.
Heart disease due to increased levels of high-density lipoprotein.
Increased risk of cancer in the lungs, mouth, pharyngeal, laryngeal, bladder and pancrease.
Increase in smoke related diseases such as ulcers, high blood pressure, osteoporosis, blood clots in legs, diabetes, heart disease, emphysema and bronchitis.
Exposure to toxins such as monoxide, asbestos, particulate matter, heavy metals and other xenobiotics.
Poor health due to lifestyle choices such as obesity, alcoholism and lack of exercise.
Heart disease for type A personality.
Surgery complications due to high levels of carbon monoxide.
Diminished production of breast milk during pregnancy due to nicotine, exposure to second hand smoke which causes changes in respiration, oxygen saturation in the infant, lower respiratory infections, and may change the intelligence and behavioural development and increase the chance of lung cancer.
Increased risk of developing cardiovascular and respiratory system conditionings and becoming an addict, high levels of acute toxicity.
5. Discuss how herb/drug interactions can modify intestinal absorption of medicines.
The use of laxatives or caffeine will decrease bowel transit time and reduce the absorption of orally administred drugs. Plants with high levels of tannins (eg Altrope belladonna, lobelia inflata), iodine, salicylates can precipitate alkaloids and interfere with some absorption of drugs (eg ephadrine, colchicine).
In the book A-Z Guide to Drug-Herb-Vitamin Interactions, editor Alan R. Gaby, M.D., investigates the most common prescription medications and their interactions with supplements. It is based on more than 4,500 known major interactions among herbs, vitamins, foods, and drugs. Below are some points covered in the book A-Z Guide to Drug-Herb-Vitamin Interactions, by Alan R. Gaby, editor.
1. Name the two dietary supplements that may be helpful if taking antibiotics and explain why they are beneficial.
The two dietary supplements that aid antibiotics are Probiotics and Vitamin K. Probiotics are beneficial because the probiotic organism such as lactobacillus casei, lactobacillus acidophilus, bifodobacterium longum and saccharomyces boulardii help prevent one of the side effects of taking antibiotics which is diarrhea. Probiotics have also been helpful in treatment of other antibiotic side effects such as clastridium infection, overgrowth of yeast in the vagina and intestines. Vitamin K is helpful in preventing the antibiotic induced bleeding effect.
2. List the five dietary supplements that may be beneficial if taking aspirin and explain why they may be needed.
The five dietary suppments beneficial when taking aspirin are:
Folic Acid – reduces the impact of the lowered levels of folic acid in people who have rheumatoid arthritis and take aspirin.
Iron – counteracts the gastrointestinal bleeding (GI) side effect of aspirin, which reduced iron deficiencies problems such as anemia.
Vitamin B12 – patients with heart disease who take aspirin have been found to have a reduced levels of Vitamin B12.
Vitamin C – Aspirin reduced Vitamin C in the body, taking Vitamin counteracts this effect.
Zinc – Aspirin lowers levels of zinc in the body, so taking zinc counteracts this effect.
3. Discuss three of the six herbs listed that may be helpful for someone taking chemotherapy. Explain why they may be recommended.
The three herbs helpful during chemotherapy are:
Echinacea – is an immune booster during chemotherapy where the immune is compromised due to the chemicals used.
Eleuthero – chemotherapy was shown to be less toxic and increased tolerance when used with eleithero. Improves the immune system as shown in studies with women with breast cancer that were treated with chemotherapy and radiation.
Milk Thistle – The major flavanoid in milk thistle is silymarin has shown synergistic actions with the chemotherpay drugs cisplatin and doxorubicin. Silymarin offsets cisplatin toxicity on the kidney.
4. Discuss the interactions with herbs and other compounds listed under the Oral Contraceptives heading. Explain why a doctor should be consulted, or why these should be avoided by someone taking oral contraceptives.
Oral Contraceptives (OC) interactions exist with St John’s wort and Tobacco. St John’s wort has been shown to cause intramenstrual bleeding and/or changes in menstrual bleeding. Tobacco used with OC increases the risk five-fold of dying from heart attack and greatly increases the risk of dying from circulatory disease.
5. Discuss the dietary supplements that may be helpful to, as well as the supplement that should be avoided by, someone prescribed tamoxifen.
Useful dietary supplements with tamoxifen are melatonin and tocotrienols. Melatonin together with tamoxifen has been successful in breast cancer, where only tamoxifen usage was unsuccessful. Tocotrienols may enhances the effects of tamoxifen in anti cancer effects but needs further studies.
Citrus flavonoids have shown to interfere with the ability of tamoxifen to inhibit tumor growth therefore should be avoided due to this adversary interaction.
The Net explores the complex back-story of Ted Kaczynski, the infamous Unabomber. An inquiry into the rationale of this notable figure situates him within a late 20th Century web of technology – a system that he grew to oppose. Incorporating a subversive approach to the history of the Internet, the documentary combines speculative travelogue and investigative journalism to trace contrasting counter cultural responses to the cybernetic revolution. Read More
Specifically, the FDA is discussing the genetic manipulation of human eggs and embryos in order to prevent inherited mitochondrial disease and treat infertility. The GMO techniques under consideration include manipulation at the mitochondrial level to replace or augment mutant rDNA and methods that could create babies with three parents.
The name chemtrails is a spin-off from contrails, which are condensation trails left behind flying aircraft. There is credible evidence that chemtrails are toxic to man, animals, and the soil.
There is current concern in the United States about the increasing number of neurodegenerative patients. Since 2000, the number of Alzheimer’s patients has increased from 4.5 million to 5.4 million in 2012, according to the Alzheimer’s Association. One in eight people 65 or older have Alzheimer’s. A yearly increase seems inevitable because of the aging population, but environmental factors also play a role.
Most people are pretty bad at taking advice from others. People don’t mind hearing the advice, they just hate to take it. This is one facet of what psychologists call the ‘egocentric bias’: the general rule that we think we know better.
The egocentric bias strikes in the boardroom, in schools, in hospitals and everywhere where two or more people are gathered together and one turns to the other and says: “What do you think?”
It’s the reason why every person and every generation has to make its own mistakes. People have a tendency not to listen until after it’s too late.
This is a real shame because a lot of the time other people have really important insights or experience that we don’t have ourselves (e.g. The Impressive Power of a Stranger’s Advice). We can’t hope to know everything ourselves.
A COMPETITIVE school market is segregating students by ability, socio-economic background and ethnicity with profound effects on education outcomes, states a report by the Organisation for Economic Cooperation and Development.
The best education systems are those that combine equity with quality and give all children opportunities, argues the report, Equity and Quality in Education: Supporting Disadvantaged Students and Schools.
It precedes a major review of funding in Australia. The Gonski review will be released on February 20 and is expected to recommend an overhaul of the funding regime with particular focus on disadvantaged public schools.
I learned at the age of 10, when I was shipped off to a New England boarding school where the hazing of younger boys was the principal form of recreation, that those who hunger for power are psychopathic bastards. The bullies in the forms above me, the sadistic masters on our dormitory floors, the deans and the headmaster would morph in later life into bishops, newspaper editors, college presidents, politicians, heads of state, business titans and generals. Those who revel in the ability to manipulate and destroy are demented and deformed individuals. These severely diminished and stunted human beings—think Bill and Hillary Clinton—shower themselves, courtesy of elaborate public relations campaigns and an obsequious press, with encomiums of piety, patriotism, devoted public service, honor, courage and vision, not to mention a lot of money. They are at best mediocrities and usually venal. I have met enough of them to know.
Bisphenol A is a chemical that is used in a wide variety of consumer products and exhibits hormone-like properties. Fetuses, infants, children or adults exposed to the chemical have been shown to exhibit numerous abnormalities, including cancer, as well as reproductive, immune and brain-behavior problems. Now, researchers have determined that daily exposure to very low concentrations of Bisphenol A by pregnant females also can cause fetal abnormalities in primates.
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